MozartV1, France, Analysis, bibRecord, 000086

Genetic polymorphisms and lipoprotein responses to diets.

Identifieur interne : 000086 ( France/Analysis ); précédent : 000085; suivant : 000087

Genetic polymorphisms and lipoprotein responses to diets.

Auteurs : Stephanie Vincent [France] ; Richard Planells ; Catherine Defoort ; Marie-Christine Bernard ; Mariette Gerber ; Joanne Prudhomme ; Philippe Vague ; Denis Lairon

Source :

The Proceedings of the Nutrition Society [ 0029-6651 ] ; 2002.

RBID : pubmed:12691171

English descriptors

KwdEn :
- Apolipoproteins A (genetics), Apolipoproteins B (genetics), Apolipoproteins E (genetics), Cardiovascular Diseases (prevention & control), Carrier Proteins (genetics), Diet, Environment, Fatty Acid-Binding Proteins, Genetic Predisposition to Disease, Humans, Lipoproteins (blood), Neoplasm Proteins, Polymorphism, Genetic, Tumor Suppressor Proteins.
MESH :
- chemical , blood : Lipoproteins.
- chemical , genetics : Apolipoproteins A, Apolipoproteins B, Apolipoproteins E, Carrier Proteins.
- prevention & control : Cardiovascular Diseases.
- Diet, Environment, Fatty Acid-Binding Proteins, Genetic Predisposition to Disease, Humans, Neoplasm Proteins, Polymorphism, Genetic, Tumor Suppressor Proteins.

Abstract

While human diets have markedly evolved since their origin, the human genome has only marginally changed. Nevertheless, polymorphisms of common genes are widespread. It has been substantiated that most major diseases (including cardiovascular disease, diabetes, obesity and cancers) result from the interaction between genetic susceptibility and environmental factors, including diet. In the field of lipoprotein metabolism and cardiovascular disease several gene polymorphisms for key proteins, such as apoproteins (apo) E, B, A-IV and C-III, LDL receptor, microsomal transfer protein (MTP), fatty acid-binding protein (FABP), cholesteryl ester transfer protein (CETP), lipoprotein lipase and hepatic lipase, have been identified and linked to variable responses to diets. We are carrying out an intervention study (RIVAGE) in Marseille dedicated to investigating the interactions between diets (Mediterranean or low-fat types v. standard Western type), risk factors for cardiovascular disease and gene polymorphisms in about 300 patients randomized into two groups over periods of 3 and 12 months. Some data obtained in about 100 patients after 3 months of dietary change are available. Among single nucleotide polymorphisms (SNP) already studied (apoE (epsilon2, epsilon3, epsilon4), apoB (-516C/T), apoC-III (SstI), apoA-IV (Ser347Thr), MTP (-493G/T), intestinal FABP (Ala54Thr), CETP (TaqIB) and hepatic lipase (-480C/T)), some SNP showed interactions with diets in relation to changes in particular variables after 3 months on the dietary regimens. This was the case for apoE and LDL-cholesterol and triacylglycerols, apoA-IV and LDL-cholesterol, MTP and LDL-cholesterol, intestinal FABP and triacylglycerols. These data provide evidence of the interaction between some SNP and the metabolic response to diets.

PubMed: 12691171

Affiliations:

Links to Exploration step

pubmed:12691171

Le document en format XML

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<affiliation wicri:level="3"><nlm:affiliation>Unité 476-Human Nutrition and Lipids at INSERM (National Institute of Health and Medical Research), 18 Avenue Mozart, 13009 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Bernard, Marie Christine" sort="Bernard, Marie Christine" uniqKey="Bernard M" first="Marie-Christine" last="Bernard">Marie-Christine Bernard</name>
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<author><name sortKey="Gerber, Mariette" sort="Gerber, Mariette" uniqKey="Gerber M" first="Mariette" last="Gerber">Mariette Gerber</name>
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<author><name sortKey="Planells, Richard" sort="Planells, Richard" uniqKey="Planells R" first="Richard" last="Planells">Richard Planells</name>
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<author><name sortKey="Defoort, Catherine" sort="Defoort, Catherine" uniqKey="Defoort C" first="Catherine" last="Defoort">Catherine Defoort</name>
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<author><name sortKey="Bernard, Marie Christine" sort="Bernard, Marie Christine" uniqKey="Bernard M" first="Marie-Christine" last="Bernard">Marie-Christine Bernard</name>
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<author><name sortKey="Gerber, Mariette" sort="Gerber, Mariette" uniqKey="Gerber M" first="Mariette" last="Gerber">Mariette Gerber</name>
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<author><name sortKey="Prudhomme, Joanne" sort="Prudhomme, Joanne" uniqKey="Prudhomme J" first="Joanne" last="Prudhomme">Joanne Prudhomme</name>
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<author><name sortKey="Vague, Philippe" sort="Vague, Philippe" uniqKey="Vague P" first="Philippe" last="Vague">Philippe Vague</name>
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<author><name sortKey="Lairon, Denis" sort="Lairon, Denis" uniqKey="Lairon D" first="Denis" last="Lairon">Denis Lairon</name>
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<series><title level="j">The Proceedings of the Nutrition Society</title>
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<term>Cardiovascular Diseases (prevention & control)</term>
<term>Carrier Proteins (genetics)</term>
<term>Diet</term>
<term>Environment</term>
<term>Fatty Acid-Binding Proteins</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Lipoproteins (blood)</term>
<term>Neoplasm Proteins</term>
<term>Polymorphism, Genetic</term>
<term>Tumor Suppressor Proteins</term>
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<term>Environment</term>
<term>Fatty Acid-Binding Proteins</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Neoplasm Proteins</term>
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<front><div type="abstract" xml:lang="en">While human diets have markedly evolved since their origin, the human genome has only marginally changed. Nevertheless, polymorphisms of common genes are widespread. It has been substantiated that most major diseases (including cardiovascular disease, diabetes, obesity and cancers) result from the interaction between genetic susceptibility and environmental factors, including diet. In the field of lipoprotein metabolism and cardiovascular disease several gene polymorphisms for key proteins, such as apoproteins (apo) E, B, A-IV and C-III, LDL receptor, microsomal transfer protein (MTP), fatty acid-binding protein (FABP), cholesteryl ester transfer protein (CETP), lipoprotein lipase and hepatic lipase, have been identified and linked to variable responses to diets. We are carrying out an intervention study (RIVAGE) in Marseille dedicated to investigating the interactions between diets (Mediterranean or low-fat types v. standard Western type), risk factors for cardiovascular disease and gene polymorphisms in about 300 patients randomized into two groups over periods of 3 and 12 months. Some data obtained in about 100 patients after 3 months of dietary change are available. Among single nucleotide polymorphisms (SNP) already studied (apoE (epsilon2, epsilon3, epsilon4), apoB (-516C/T), apoC-III (SstI), apoA-IV (Ser347Thr), MTP (-493G/T), intestinal FABP (Ala54Thr), CETP (TaqIB) and hepatic lipase (-480C/T)), some SNP showed interactions with diets in relation to changes in particular variables after 3 months on the dietary regimens. This was the case for apoE and LDL-cholesterol and triacylglycerols, apoA-IV and LDL-cholesterol, MTP and LDL-cholesterol, intestinal FABP and triacylglycerols. These data provide evidence of the interaction between some SNP and the metabolic response to diets.</div>
</front>
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<tree><noCountry><name sortKey="Bernard, Marie Christine" sort="Bernard, Marie Christine" uniqKey="Bernard M" first="Marie-Christine" last="Bernard">Marie-Christine Bernard</name>
<name sortKey="Defoort, Catherine" sort="Defoort, Catherine" uniqKey="Defoort C" first="Catherine" last="Defoort">Catherine Defoort</name>
<name sortKey="Gerber, Mariette" sort="Gerber, Mariette" uniqKey="Gerber M" first="Mariette" last="Gerber">Mariette Gerber</name>
<name sortKey="Lairon, Denis" sort="Lairon, Denis" uniqKey="Lairon D" first="Denis" last="Lairon">Denis Lairon</name>
<name sortKey="Planells, Richard" sort="Planells, Richard" uniqKey="Planells R" first="Richard" last="Planells">Richard Planells</name>
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<name sortKey="Vague, Philippe" sort="Vague, Philippe" uniqKey="Vague P" first="Philippe" last="Vague">Philippe Vague</name>
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<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Vincent, Stephanie" sort="Vincent, Stephanie" uniqKey="Vincent S" first="Stephanie" last="Vincent">Stephanie Vincent</name>
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Genetic polymorphisms and lipoprotein responses to diets.

Genetic polymorphisms and lipoprotein responses to diets.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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